Dr. David Loeb graduated from Johns Hopkins University and then moved to New York and obtained his MD and PhD from the Columbia University College of Physicians and Surgeons. He returned to Johns Hopkins, where he completed his internship and residency in Pediatrics and his fellowship in Pediatric Hematology and Oncology. He joined the faculty at Johns Hopkins, where he practiced and performed research for 17 years. Dr. Loeb joined the faculty at Children’s Hospital at Montefiore (CHAM), where he serves as Director of Pediatric Hematology, Oncology, and Marrow & Blood Cell Transplantation, in 2017. He is also a member of the Department of Developmental and Molecular Biology at the Albert Einstein College of Medicine.
Dr. Loeb is Director of the Sarcoma Program and is a member of the Bone Marrow Transplant Program at CHAM. He also has expertise in the care of children with other solid tumors, with acute myeloid leukemia and in the application of immunotherapy to childhood cancer. Dr. Loeb has an active translational research laboratory focused on understanding bone tumor metastasis. His laboratory developed a clinically relevant mouse model of sarcoma metastasis, and has used this model to perform preclinical testing of novel agents that can interfere with this process. In addition, Dr. Loeb is also studying the role of an enzyme called RNA helicase DDX3 in Ewing’s Sarcoma biology, especially how this enzyme affects the repair of damaged DNA. Dr. Loeb is also actively involved in clinical research, including the development of radiopharmaceutical agents for the treatment of bone metastases and the development of a small molecule inhibitor of DDX3. He serves as the Coordinating Physician for an international Phase I study of an immune checkpoint inhibitor for pediatric solid tumors, and he has directed a clinical trial of reduced intensity haploidentical bone marrow transplantation for children with high risk solid tumors. As an offshoot of his laboratory work, Dr. Loeb is involved in the development of biomarkers of metastatic risk and of minimal residual disease in children, adolescents, and young adults with sarcomas.
Warren Alperstein, MD, is Assistant Professor of Hematology/Oncology/Bone Marrow Transplants at the University of Miami in Florida, as well as Assistant Professor of Clinical Pediatrics. He is a graduate of Technion Medical School at the Israel Institute of Technology and obtained his BS in Child Development at the University of Illinois at Urbana-Champaign. Dr. Alperstein completed his internship and residency in pediatrics at the University of Chicago, Comer Children’s Hospital, and won a fellowship in pediatric bone marrow transplantation at Jackson Memorial Hospital, in Miami, Florida.
Warren was awarded a Hyundai Hope Scholar Grant in 2019 in the amount of $300,000 to investigate “High-Throughput Drug Screen for Pediatric Sarcomas”. He is the author or collaborator for numerous professional publications, including “Pediatric Acute Lymphoblastic Leukemia: From Diagnosis to Prognosis”, “Ewing Sarcoma: Evidence-Based Diagnosis & Management”, “An Extra-Renal Wilms’ Tumor Presenting as a Uterine Mass”, “Undifferentiated Sarcoma: A Unique Infant Case Report”, “Successful Treatment with Plaque Brachytherapy in Recurrent Relapsed Retinoblastoma”, “The Impact of Medical & Psychosocial Factors on the Quality of Life in Children with Cancer & Their Families – Pediatric Blood & Cancer”, as well as an article in the Miami Herald entitled “Pediatric Cancer: Warning Signs and Symptoms”.
Dr. Alperstein is a member of the American Academy of Pediatrics, Children’s Oncology Group, American Society of Clinical Oncology, and American Society for Blood & Marrow Transplantation. At the University of Miami, he holds a number of positions, including core faculty educator for the Department of Pediatrics, Chemo Team committee member, Simulation Laboratory instructor, coordinator for Pediatric Hematology/Oncology Tumor Board, and member of the Holtz Pediatric Hematology/Oncology PI Committee.
Warren is married with children. In his spare time, he is active in Chai Life Line – a leading international children’s health support network that provides social, emotional and financial support to children with life-threatening or lifelong illnesses and their families. Additionally, he is a supporter of all Chicago-based sports teams.